9 Proven Black Seed Oil Benefits that Boost Your Health 

Dr. Josh Axe, DC, DMN, CNS 

 Made from the seeds of the black cumin plant is black seed oil, and it has been used  throughout the centuries as a spice or an herbal medicine. Researchers reported that black seed  oil can combat against different strains of bacteria and viruses that are antimicrobial and people  infected with superbugs. This oil is highly rich in these three natural chemicals:  Thymohydoquinone—used to treat autism, glaucoma, dementia, neurodegenerative conditions,  schizophrenia, etc.; Thymoquionone—has antioxidant, anti-inflammatory, and anti-cancer  properties; and Thymol—frequently used to kill TB, other viruses, and even perfumes, food a  wildly benefits hair, treats infections, improves fertility, and balances cholesterol. It has been  reported that back seed may cause an allergic reaction when applied directly to the skin or  ingested by mouth.  


A review on therapeutic potential of Nigella sativa: A miracle herb

Aftab Ahmad, Asif Husain, Mohd Mujeeb, Shah Alam Khan, Abul Kalam Najmi,  Nasir Ali Siddique, Zoheir A. Damanhouri, and Firoz Anwar 

There is a widely used medicinal plant known as N. Sativa that has been used a variety of  traditional system of medicine for the treatments of different diseases and ailments. Because of  its miraculous powers of restoration, it has been ranked very high on the list for herbal medicine.  Throughout history it has been used as liver tonics, diuretics, antihypertensive, digestive, anti diarrheal, appetite stimulant, and analgesics. The main bioactive compound in the plant,  thymoquinone, is responsible for most of the therapeutic properties found din the plant. Research  has reported the pharmacological activities of N. Sativa including anti-diabetic, anti-cancer,  immnomodulator, antimicrobial, anti-inflammatory, bronchodilator, hepato-protective, renal  protective, gastro-protective, antioxidant properties, and many more. N. Sativa seeds, its oil, and  its constituents could be used as therapeutic candidate to treat infectious diseases and to  overcome distance problems.  


Anticancer Activities of Nigella Sativa (Black Cumin)

Md Asaduzzaman Khan, Han-chun Chen, Mousumi Tania, and Dian-zheng Zhang 

 Nigella sativa is a centuries old traditional medicine, and the extract from its and oil,  crude oil and thymoquinone, are useful when combating diseases such as cancer, diabetes,  cardiovascular complications, kidney disease, asthma, and diabetes. There still needs more  research on its anticancer activity; however, there are many studies that showed that the  thymoquinone in nigella sativa has antioxidant properties and improves the body’s defense  system. Also, it has been reported that its oil can protect cells from radiation. More research is  still needed, but N. Sativa may be a great candidate for new anti-cancer strategies.  


What Is Black Seed Oil? All You Need to Know Kelli McGrane, MS, RD and Natalie Butler, R.D., L.D. 

For over 2,000 years, black seed oil has been used for traditional medicine because of its  many health benefits. For one, this oil is high in antioxidants so this compound may protect brain  health and help in treating several types of cancer. It may help treat asthma because research has  shown it can reduce inflammation and rely muscles in the airway. One study was conducted on if  black seed oil can aid in weight loss; the results showed significant improvements in triglyceride  and bad cholesterol levels. Black seed oil may lower blood sugar levels and reduce chances of  getting future complications like eye disease, kidney disease, and stroke. It may help lower blood  pressure, cholesterol levels, and protect brain health. Also, this compound may be good for skin  and hair to help treat skin conditions like acne, eczema, psoriasis, and dry skin due to its anti microbial and anti-inflammatory effects.  


Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19

Mohammad Tariqur Rahman 

 A variety of different antiviral drugs have been used to treat the COVID-19 pandemic.  Nigella sativa was found to be a natural substitute because it contains a number of bioactive  components including thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine.  Used with a zinc supplement, the effectiveness of N. Sativa could be enhanced. Using N. Sativa  as a way to treat COVID-19 can block the entry of the virus into pneumocytes and provide  ionophore for enhanced uptake of zinc ion which in turn can enhance host immune response  against SARS-CoV-2. In addition, it can slow down its reapplication by blocking the viral RNA dependent RNA polymerase. Studies have reported that the usage of black seed oil for daily  doses between 40-80 mg/kg a day showed no side effects in patients.  


Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

Muhammad Fakhar-e-Alam Kulyar, Rongrong Li, Khalid Mehmood, Muhammad  Waqas, Kun Li, and Jiakui Li 

 The race to find a suitable treatment of COVID-19 has been paramount. The components of  nigella sativa, a medicinal plant, have intense anti-inflammatory, immune-regulatory, and antioxidant  benefits in obstructive respiratory disorders. These components, especially thymoquinone, can be a  potential candidate in strengthening the immune-regulatory effects on COVID-19. The thymoquinone suppresses mRNA expression which down regulates interferon genes or a family of naturally occurring  proteins and other inflammatory responses. Further in vitro and in vivo studies are needed to fully  understand the extent of this compound’s therapeutic effects.  


Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Alireza Tavakkoli,1 Vahid Mahdian,2 Bibi Marjan Razavi,3 and Hossein  Hosseinzadeh 

Nigella sativa or black seed, along with its major constituent thymoquinone (TQ), is a  medical herb with many health benefits. A study investigated the therapeutic effects of N. Sativa  and TQ in the prevention and treatment of different diseases and morbidity conditions in humans.  The results reported that both had multiple useful effects for the treatment of patients with  diseases including autoimmune and inflammatory disorders, metabolic syndromes; as well as  properties including anti-nociceptive, antimicrobial, and anti-epileptic. Researchers have  understood the hypoglycemic, hypolipidemic and bronchodilatory effects of N. Sativa, which  thereby enables the next stage of trials for drug developments.  


Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID19 prevention and cure

Mohammad Nazrul Islam, Khandkar Shaharina Hossain, Partha Protim Sarker,  Jannatul Ferdous, Md. Abdul Hannan, Md. Masudur Rahman, Dinh-Toi Chu, and  Md. Jamal Uddin 

Nigella sativa is a well-known effective herb that can establish a balanced inflammatory  response through the suppression of chronic inflammation and the promotion of a healthy  immune response. N. Sativa, especially its oil extract, has been used to combat immune  disturbance, oxidative stress, autophagy dysfunction, and ischemia. Black seed oil may be able to  help fight against COVID-19 because of one of the many pharmacological benefits of the seed  and its active metabolites have. The compounds of black seed, thymiquinone, α-hederin, and  nigellidine showed to have promising results for it to made a therapeutic drug; however, more  preclinical and clinical trials are required to investigate their efficacy and potency.