Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Adrian R Martineau, David A Jolliffe, Richard L Hooper, Lauren Greenberg, John F Aloia, Peter Bergman, Gal Dubnov-Raz, Susanna Esposito, Davaasambuu Ganmaa, Adit A Ginde, Emma C Goodall, Cameron C Grant, Christopher J Griffiths, Wim Janssens, Ilkka Laaksi, Semira Manaseki-Holland, David Mauger , David R Murdoch, Rachel Neale , Judy R Rees, Steve Simpson Jr, Iwona Stelmach, Geeta Trilok Kumar, Mitsuyoshi Urashima, Carlos A Camargo Jr
The goal is to determine the overall effect of vitamin D supplementation on the risk of acute respiratory tract infection, as well as the factors that influence it. Conceptualization Individual participant data (IPD) from randomized controlled trials underwent a systematic review and meta-analysis. Acute respiratory tract infections are a leading source of morbidity and mortality worldwide, accounting for 10% of ambulatory and emergency department visits in the United States and 2.65 million deaths globally in 2013. The quality of the evidence that went into these studies was rated as excellent. Final Thoughts Vitamin D supplementation was found to be safe and effective in preventing acute respiratory tract infection. Patients with severe vitamin D deficiency and those who did not get bolus doses benefited the most.