Genetic detoxification of bacterial toxins: A new approach to vaccine development
R Rappuoli, G Douce, G Dougan, and M Pizza
For preventing a variety of different bacterial infectious diseases, toxoids or chemically detoxified bacterial toxins, have been successfully used as vaccines. Superior to the classical toxoids both in safety and in immunogenicity, genetically inactivated toxins should replace the classical toxoids in vaccines. For the innovative approaches to vaccination, genetically inactivated toxins represent a novel class of immunogens with unique properties.